Doesn't work really well out of the box. Why ?

See if you can spot the mistake between these two pictures. One of them is a picture of the IPV4 stack listening and the next one shows the IPV6 stack listening. If you've installed the RPC over HTTP proxy and enabled Outlook Anywhere on your CAS on Windows 2008, issue a Netstat -a -n and you' see the 6001, 6002, 6004 ports are listening on IPv4 but not IPv6

I found a terrific write up on this here on Aaron Marks blog. In a nutshell, you're looking to do a host file edit and add your machine name and IPv4 address, plus disable IPV6 in the registry and reboot. Well done again Aaron!