Since we hit these so oten, I thought it would be cool to post this one, even if you've bumped into it allready:
Top support issues for the Exchange information store
Seeig this list crop up so often, it's nice to have a KB article to refer to that has most of them, especially if you see a EvenT ID 1018 at 3 in the morning 😉
Third-party antivirus or backup software contention